How and/or why HMM could be useful in Biotechnology?Discuss pros and cons of PSI-BLAST in compared to the regular protein BLAST (blastp)?

Bioinformatic Homework

How and/or why HMM could be useful in Biotechnology?

In your opinion, what are the pluses and minuses for Delta-BLAST compared to PSI-BLAST?

Discuss pros and cons of PSI-BLAST in compared to the regular protein BLAST (blastp)?

How would you assess homology in putative homologs found by PSI-BLAST.