Psychopharmacology/Neuroscience: Drug treatments for OCD
Critical Review
The final assignment for this class will be a 10-12 page critical review of the drug treatment for OBESSIVE-COMPULSIVE DISORDER.
The review will use peer-reviewed and/or scholarly sources to provide an evidence base for the evaluation of current drug treatment modalities for the disorder.
The paper will be evaluated on the inclusion of the following information:
Introduction:
Evaluate OCD in terms of symptomatic and behavioral presentation.
Include the time, course, and progression of OCD.
Evaluate and explain special features of OCD epidemiology including risk factors for development of the disorder, lifespan and reproductive factors increasing risk of developing the disorder, and any genetic, environmental, or behavioral factors that increase risk.
Theory:
Evaluate the predominant theory or theories regarding the biological basis of obsessive-compulsive disorder (OCD).
Explain the OCD in terms of pertinent neurotransmitter and receptor theories and use your references to provide an evidence base for these theories.
Analyze neurotransmitter system(s) involved in the pathology of OCD, including a description of:
1) the involved neurotransmitter(s) and receptor(s)
2) regions of the nervous system (brain, spinal cord, or peripheral nervous system) involved with any pathological anatomical changes
3) abnormalities of neural circuits and pathways.
Include an explanation of how receptor agonists or antagonists would theoretically treat OCD to reverse the pathology and restore normal function, or why they would be expected to improve symptoms.
Treatment:
Evaluate drug therapies for treating the OCD based on the current understanding of the biological basis of the disorder.
Include a description of the behavioral symptoms and physical signs of OCD and identify the drug class(es) used in pharmacological therapy with a discussion of the mechanism of action of the drug class(es). (i.e. some classes of medications: glutamatergic agents, antipsychotics, and 5HT-3 antagonists, etc.)
Drug classes and drug types are not to be confused as they are two different things when explaining drug treatments.
Explain why the pharmacodynamics of the drug class(es) would affect the pathology of OCD to restore function and/or improve symptoms.
Include a discussion of the drug pharmacokinetics for each drug class.
Provide examples of available marketed drugs within each class.
Describe any drug side effects and/or adverse effects of the drug treatment and their biological basis, including issues related to contraindications, interactions, drug metabolism, and elimination.In addition, explain risks, benefits, and ethical implications for high-risk and exceptional treatment conditions.
