Explain the pathophysiology of acute SCD crisis. Why is pain the predominate feature of acute crises? What is the pathophysiology of Hemophilia?

Question
Explain what ALL is?

Why does ARF occur in some patients with ALL?

Explain the pathophysiology of acute SCD crisis. Why is pain the predominate feature of acute crises?

Discuss the genetic basis for SCD.

What is the pathophysiology of Hemophilia?